The First Church in Roxbury, also known as the First Church of Roxbury is the current headquarters of the Unitarian Universalist ("UU") Urban Ministry. A church on this site has been in use since 1632 when early English settlers built the first meetinghouse.

Since then, the meetinghouse has been rebuilt four times, and its appearance today reflects how the meetinghouse looked in the late 19th and early 20th centuries.

The First Church of Roxbury was the sixth church to be gathered by the early English settlers. In 1631, settlers living in Roxbury, who belonged to the Church of Dorchester, were finally self-sufficient enough to create their own church—the First Church of Roxbury. The "official" beginning of the church is recognized as when the first meeting house was constructed the next year. The first meetinghouse served as a central part of the community from 1632–1674.